Effect of smoking on gastric histology in Helicobacter pylori-positive gastritis. The unique microbiologic characteristics of this organism, such as urease production, allows it to alkalinize its microenvironment and survive for years in the hostile acidic environment of the stomach, where it causes mucosal inflammation and, in some individuals, worsens the severity of peptic ulcer disease. In a retrospective population-based study that evaluated long-term mortality in patients who underwent surgery for perforated peptic ulcer, mortality was Pediatr Infect Dis J. Share Email Print Feedback Close.
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