Rugarli

New Lab member We would like to welcome Mujeeb in our lab. Thus, the group is using in vivo models to investigate the role of the mitochondrial m-AAA protease in neurodegeneration. Elena Rugarli, the CECAD working group is exploring hereditary spastic paraplegia HSP , a group of rare genetic disorders causing the degeneration of axons of the corticospinal tract. Welcome and have a fun and successful time! The ultimate goal is to identify a common process responsible for axonal degeneration independent from the defective gene product.

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Congratulations from the entire lab to your very good Bachelor thesis, we wish you all the We hope you enjoy your time in The eugarli of scientists has succeeded in identifying crucial pathogenic mechanisms that underlie the disease.

Ultimately, we aim to a better understanding of the pathophysiology of this disease, and to unravel possible therapeutic avenues. Rugarli is currently working on understanding the function of several genes that contribute to the pathogenesis of HSP with the goal of dividing them into functional groups. Rgarli encodes for spastin, a protein which breaks microtubules along their length.

Research Principal Investigators Prof. Publications Publications Publications Publications Publications Publications Publications Publications Publications Thus, the group is using in vivo models to investigate the role of the mitochondrial m-AAA protease in neurodegeneration.

With her team, Prof.

Axon degeneration is a characteristic event in many neurodegenerative diseases. Dysfunctional mitochondria can trigger apoptotic cell death, and play an important role in the pathogenesis of several diseases, including hereditary spastic paraplegia. Rugarli and her group are exploring the mechanisms underlying premature axon death. After 3 years of successful work in the Rugarli lab, David continues to work on the biology of mitochondria in the lab of Prof.

New lab member We would like to welcome Marta to the Rugarli lab! He will be working on hereditary spastic paraplegia.

Addio allo scrittore Giampaolo Rugarli - modellingadvice.info

The team of scientists led by Prof. Matthias Hammerschmidt PD Dr. Page 1 of 2.

Goodbye David After 3 years of successful work in the Rugarli lab, David continues to work on the biology of mitochondria in the lab of Prof. Andreas Wodarz PD Dr.

We would like to welcome Matteo as a new PhD student in our lab. The ultimate goal is to achieve a deeper understanding of the processes in the mitochondria that lead to degeneration and how neurons might be protected in future.

We study the function of several proteins involved in hereditary spastic paraplegia, a disease characterized by degeneration of the corticospinal axons. This would make it possible to use the same treatment approach on as many patients as possible with a range of tugarli genetic defects.

Downregulation of CLUH leads to clustering of mitochondria close to the nucleus. Premature axon death occurs preferentially in long neurons, such as the corticospinal tract that runs from the cerebral cortex into the spinal cord with axons up to one meter long.

Hans Christian Hennies Dr.

Our lab is interested in two main topics:

Her research focuses primarily on hereditary spastic paraplegia HSP. Fiona successfully finished her Bachelor Thesis in our lab! We are investigating post-transcriptional mechanisms of regulation of mitochondrial biogenesis, as well as quality control pathways that are crucial to maintain the organelle function.

Welcome and have a fun and successful time!

New lab member We would like to welcome Matteo as a new PhD student in our lab. Goodbye Fiona Fiona rugaril finished her Bachelor Thesis in our lab! Another goal of the group is to understand a possible role of spastin and other HSP genes in lipid metabolism, an approach that could hold promises to find novel therapeutic strategies for HSP.

Axon rugafli is a process that plays an important role in many neurodegenerative diseases.

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