Archived from the original on 20 December The Journal of dermatological treatment. Detailed information Professionals Summary information Polski , pdf. This latter effect is caused by 5-FU-induced damage to the oligodendrocytes that produce the insulating myelin sheaths.
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This is significant because fluorine-containing organic compounds exist only rarely in nature, and also because manmade anticancer drugs are not frequently found to have analogues in nature. The Journal of dermatological treatment. Fluororuacilo we make recommendations for managing patients being treated with 5-fluorouracil. Summary [ edit ] Description 5-Fluorouracilo. Expert Opinion on Therapeutic Patents.
I, the copyright holder of this work, hereby publish it under the following licenses:. Additional information Further information on this disease Classification s 1 Gene s 0 Other website s 0. Summary and related texts. Women have been reported to experience more 5-FU-related toxicity than men. Permission Reusing this file. Charles Heidelbergerwho had earlier found that fluorine in fluoroacetic acid inhibited a vital enzyme, asked Robert Duschinsky and Robert Schnitzer at Hoffman-La Roche to synthesize fluorouracil.
Click on genes, proteins and metabolites below to link to respective articles.
This fluorourxcilo was last edited on 6 Septemberat This latter effect is caused by 5-FU-induced damage to the oligodendrocytes that produce the insulating myelin sheaths.
You may select the license of your choice. Oesophagitis GI ulceration and bleeding Proctitis Nail disorders Vein pigmentation Confusion Cerebellar syndrome Encephalopathy Visual changes Photophobia Lacrimation the expulsion of tears without any emotional or physiologic reason.
Carboquone Thiotepa Triaziquone Triethylenemelamine. It is contraindicated in patients that are severely debilitated or in patients with bone marrow suppression due to either radiotherapy or chemotherapy.
Get Access Get Access. Results of a multicenter randomized trial of patients with metastatic colorectal cancer".
Administration of 5-FU causes fluoroueacilo scarcity in dTMP, so rapidly dividing cancerous cells undergo cell death via thymineless death. Basic Science to the Clinic.
Treatment with 5-fluorouracil is common in oncological patients. Archived from the original on Archived from the original on 1 February Archived from the original on 20 December This licensing tag was added to this file as part of the GFDL licensing update.
Orphanet: Toxicidad por 5 fluorouracilo
Ffluorouracilo clave Angina instable. Only comments written in English can be processed. Clinical Pharmacology and Therapeutics. This page was last edited on 11 Augustat Pharmacy and pharmacology portal Medicine portal.