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Biopharmaceutics and pharmacokinetics : a treatise
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Need for drug biotransformation Drug metabolising organs Drug metabolising enzymes Chemical pathways of drug biotransformation Phase I reactions Oxidative reactions Reductive reactions Hydrolytic reactions Phase II reactions Conjugation with glucuronic acid Conjugation with sulphate moieties Conjugation with alpha amino acids Conjugation with glutathione and mercapturic acid formation Acetylation Methylation Miscellaneous conjugation reactions Fate of metabolites following biotransformation in liver Presystemically formed vs systemically formed metabolites Methods for the study of drug biotransformation Factors affecting biotransformation of drugs Physicochemical properties of the drug Chemical factors Biological factors Brah,ankar and tissue toxicity Biopharmaceutics drug disposition classification system Questions.
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Biopharmaceutics and Pharmacokinetics--A Treatise by Brahmankar,Jaiswal
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